Effect of Psoralea corylifolia on dexamethasone-induced insulin resistance in mice

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Psoralea corylifolia L. Seed Extract Ameliorates Streptozotocin-Induced Diabetes in Mice by Inhibition of Oxidative Stress

Pancreatic beta-cell death is known to be the cause of deficient insulin production in diabetes mellitus. Oxidative stress is one of the major causes of beta-cell death. In this study, we investigated the effects of Psoralea corylifolia L. seed (PCS) extract on beta-cell death. Oral administration of PCS extract resulted in a significant improvement of hyperglycemia in streptozotocin-induced di...

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Protective Effect of Psoralea corylifolia L. Seed Extract against Palmitate-Induced Neuronal Apoptosis in PC12 Cells

The extract of Psoralea corylifolia seeds (PCE) has been widely used as a herbal medicine because of its beneficial effect on human health. In this study, we investigated the protective effects and molecular mechanisms of PCE on palmitate- (PA-) induced toxicity in PC12 cells, a neuron-like cell line. PCE significantly increased cell viability in PA-treated PC12 cells and showed antiapoptotic e...

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Effect of Vanadyl Sulfate on Fructose-Induced Insulin Resistance Rat

Insulin resistance syndrome, also referred to as the metabolic syndrome or syndrome X, refers to a constellation of common metabolic and cardiovascular disorders (e.g. obesity, type 2 diabetes mellitus, hypertension, and dyslipidemia), which are all cardiovascular risk factors. Insulin resistance can be induced by fructose-rich diet in rats. We investigated the effect of vanadyl sulfate (0.2 mg...

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Protective Effect of Pentoxifylline on Sperm and Biochemical Parameters against Dexamethasone-Induced Toxicity in Mice

Background and purpose: Nowadays, the side effects of chemical drugs such as dexamethasone, as a steroidal anti-inflammatory factor, is considered on reducing male reproductive potential. The aim of this study was to evaluate the effect of pentoxifylline on sperm parameters and biochemical factors in mice treated with dexamethasone. Materials and methods: In this study, 24 adult male NMRI mice...

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ژورنال

عنوان ژورنال: Journal of King Saud University - Science

سال: 2012

ISSN: 1018-3647

DOI: 10.1016/j.jksus.2011.03.007